Cleavage of unreactive bonds for asymmetric synthesis

2014 Fiscal Year Final Research Report

• Project Area: Molecule Activation Directed toward Straightforward Synthesis
• Project/Area Number: 22105005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: MURAKAMI Masahiro 京都大学, 工学(系)研究科(研究院), 教授 (20174279)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 合成化学 / 炭素－炭素結合 / 分子活性化 / 不斉合成 / 遷移金属触媒

Outline of Final Research Achievements

In this project, we have embarked on the development of new enantioselective synthetic methods based on cleavage of C-C bonds by transition metal catalysis. For example, we have developed (1) reactions to insert unsaturated molecules into a C-C bond in an enantioselective manner, (2) methods to reconstruct carbon frameworks enantioselectively through cleavage and formation of C-C bonds. These new synthetic reactions offer efficient ways to construct complex organic skeletons that are otherwise difficult to access.

Free Research Field

有機金属化学