Regulation of Reactivity of Highly Reactive Species by Utilizing Large Molecular Cavities

2014 Fiscal Year Final Research Report

• Project Area: Molecule Activation Directed toward Straightforward Synthesis
• Project/Area Number: 22105011
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: GOTO Kei 東京工業大学, 理工学研究科, 教授 (70262144)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 有機化学 / 物質変換 / 分子活性化 / 活性種 / 分子空孔

Outline of Final Research Achievements

In the active site of enzymes, reactive species that are very unstable in artificial systems are sometimes stabilized and play an important role in bioactivation of substrate molecules with extraordinarily high reactivity. For modeling such fabulous features of enzymatic reactions, various types of nano-sized molecular cavities were synthesized and applied to molecular activation. Development of novel synthetic reactions by taking advantage of unique features of reactive intermediates of enzymatic reactions as well as modeling of bioactivation of small molecules such as reactive nitrogen species were investigated.

Free Research Field

有機元素化学