Fine Design and Synthesis of Fusion Materials Based on Functionalized Peptides

2014 Fiscal Year Final Research Report

• Project Area: Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control
• Project/Area Number: 22107005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Nagoya University (2013-2014); The University of Tokyo (2010-2012)
• Principal Investigator: NARUTAKI AYAE 名古屋大学, 工学(系)研究科(研究院), 准教授 (10508203)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ハイブリッド材料 / 機能性高分子 / 融合マテリアル / 生体材料 / 高分子構造・物性

Outline of Final Research Achievements

Novel elastin-like polypeptides have been developed as control molecules for the creation of fusion materials. The polypeptides consist of several functional blocks, the design of which was inspired by the domain structure of native elastin. The polypeptides form well-defined nanofibers in aqueous solution by external stimuli. The silver-binding sequence was fused to the elastin-like polypeptide to give silver nanoparticle-polypeptide nanofiber composite materials that show anti-bacterial properties. Hybrid scaffold was fabricated from the polypeptide fiber and a biocompatible polymer. As a collaborative research in the project, polymer-mediated self-assembly of inorganic nanoparticles was conducted. Unique ring-like nanostructure of silica nanoparticles was obtained in the liquid phase by using synthetic block copolymer as a mediator.

Free Research Field

高分子材料化学