Function Exploration of Nano-Fusion Molecular Assemblies for Biomedical Applications

2014 Fiscal Year Final Research Report

• Project Area: Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control
• Project/Area Number: 22107011
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Hiroshima University (2011-2014); Nagoya University (2010)
• Principal Investigator: KATAGIR Kiyofumi 広島大学, 工学(系)研究科(研究院), 准教授 (30432248)
• Co-Investigator(Kenkyū-buntansha): TOMITA Koji 東海大学, 理学部, 講師 (00419235)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 融合マテリアル / バイオメディカル材料 / ドラッグデリバリー / 光線力学療法 / アップコンバージョン蛍光体 / ナノ粒子

Outline of Final Research Achievements

Biomineralization is used to produce minerals found in nature, and is an attractive strategy for materials synthesis. Molecular control is key in this process, and biomolecules precisely control the crystallization of inorganic substances. In this project, environmentally friendly hybrid materials that are comparable to biotic materials will be synthesized by mimicking biomineralization. In this project, we have developed hierarchically structured materials by fusing and assembling flexible organic molecules. We have also developed novel dynamic functions that cannot be achieved by simple conjugation of soft and hard materials. We have successfully developed fusion materials for photodynamic therapy via NIR irradiation, magnetoresponsive smart capusule, polysaccharide-iron oxide nanofusion materials as MRI contrast agent and magnetic hyperthermia therapy, and nanofusion particles for boron neutron capture therapy.

Free Research Field

材料化学