Mechanic analysis of biosynthetic machinery for microbial secondary metabolites

2014 Fiscal Year Final Research Report

• Project Area: Biosynthetic machinery: Deciphering and regulating the system for bioactive metabolite diversification
• Project/Area Number: 22108003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: EGUCHI Tadashi 東京工業大学, 理工学研究科, 教授 (60201365)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 生合成 / 抗生物質 / 生合成酵素 / 遺伝子クラスター

Outline of Final Research Achievements

Natural product biosynthesis has long been affording interesting and important organic compounds. The biosynthetic systems are apparently a sort of designer assembly line. Recent advances in genetics and molecular biology as well as chemical technology will be beneficial in understanding the precise nature of the biosynthetic machinery and in engineering the machinery to produce natural and unnatural products. In this project, our own approach to this field, particularly focusing on the mechanistic enzymology as well as genetic analysis of biosynthesis of several macrolactam (vicenistatin, incednine, cremimycin, and hitachimycin) and aminoglycoside antibiotics (neomycin, butirosin, and kanamycin), was performed.

Free Research Field

天然物有機化学