Elucidation of dynamic pathologies of developmental and neurodegenerative diseases

2014 Fiscal Year Final Research Report

• Project Area: Generation of synapse-neurocircuit pathology
• Project/Area Number: 22110002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OKAZAWA Hitoshi 東京医科歯科大学, 難治疾患研究所, 教授 (50261996)
• Co-Investigator(Renkei-kenkyūsha): ENOKIDO Yasushi 東京医科歯科大学, 難治疾患研究所, 准教授 (90263326) ; TAMURA Takuya 東京医科歯科大学, 難治疾患研究所, 助教 (80396647) ; SONE Masaki 東京医科歯科大学, 難治疾患研究所, 特任講師 (00397548) ; KOMURO Akihiko 東京医科歯科大学, 難治疾患研究所, 特任助教 (60532950)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 神経変性疾患 / 発達障害 / シナプス / 神経回路 / 分子病態

Outline of Final Research Achievements

By in vivo imaging with two-photon microscopy and by live imaging with confocal microscopy, we revealed the pathological processes from molecular dysfunctions to synapse dysfunctions in Alzheimer’s disease, polyglot diseases, intellectual disability and microcephaly. Moreover, we showed the possibility of AAV-based gene therapies to restore molecular dysfunctions in the brain and to recover the symptoms of spinocerebellar ataxia, intellectual disability and microcephaly and to improve synapse level abnormality of Alzheimer’s disease in each mouse model.

Free Research Field

神経科学