Crosstalk between epithelia and the basement membrane controlling gonadogenesis in C. elegans

2014 Fiscal Year Final Research Report

• Project Area: Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular systems
• Project/Area Number: 22111005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kwansei Gakuin University
• Principal Investigator: NISHIWAKI Kiyoji 関西学院大学, 理工学部, 教授 (30342827)
• Co-Investigator(Renkei-kenkyūsha): TAKAGI Shin 名古屋大学, 理学(系)研究科(研究院), 准教授 (90171420)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 細胞移動 / 基底膜 / 上皮細胞 / 細胞骨格 / 線虫

Outline of Final Research Achievements

The migration of gonadal leader cells (DTCs) is regulated by the extracellular matrix (ECM) as well as by their cytoskeleton in C. elegans. In this study, we found that GON-1 (matrix metalloprotease) and fibulin-1 (ECM molecule) act antagonistically to regulate the metabolism of type IV collagen and that VAB-10, a cytoskeletal linker protein, acts in cell and nuclear migration through regulating polarized outgrowth of DTC microtubules. We also showed that MIG-39, a nuclear protein, acts with Rho family GTPases to halt DTC migration.

Free Research Field

発生生物学