The intrinsic regulatory system of tumor vascularization

2014 Fiscal Year Final Research Report

• Project Area: Integrative Research on Cancer Microenvironment Network
• Project/Area Number: 22112006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: vasohibin-1 / vasohibin-2 / 血管内皮細胞 / 血管新生 / がん細胞 / がん転移

Outline of Final Research Achievements

Vasohibin-1 (VASH1) is an angiogenesis inhibitor expressed in endothelial cells, and the defect of its expression in ECs results in the enhancement of hematogenous and lymphatic cancer metastasis. There are 2 VASH1 proteins, a full length VASH1A and a splicing variant VASH1B. VASH1A causes angiogenesis inhibition and vascular maturation, whereas VASH1B causes endothelial cell death and vascular regression. Vasohibin-2 (VASH2) is an angiogenesis stimulator expressed in cancer cells, and the inhibition of its expression is useful for the anti-cancer treatment. VASH1 and VASH2 are highly conserved and resemble proteins. We analogized their active sites, developed neutralizing antibodies and identified a VASH receptor candidate.

Free Research Field

血管生物学