2014 Fiscal Year Final Research Report
Global survey of the prostaglandin receptor-mediated biological actions
| Project Area | Machineries of bioactive lipids in homeostasis and diseases |
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| Project/Area Number |
22116003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Soken 熊本大学, 大学院生命科学研究部, 講師 (80423002)
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| Co-Investigator(Renkei-kenkyūsha) |
SEGI Eri (NISHIDA Eri) 東京理科大学, 基礎工学部, 准教授 (70378628)
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| Research Collaborator |
INAZUMI Tomoaki 熊本大学, 生命科学研究部, 助教 (80746503)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | プロスタノイド / エイコサノイド / GPCR / シグナル伝達 / 発生 / 雌性生殖生理 / 発現プロファイル / 脂肪細胞 |
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| Outline of Final Research Achievements |
We characterized and established molecular nature of 12 types of prostaglandin (PG) receptors in zebrafish. Based on the information, we surveyed possible contribution of PG receptor to developmental processes of zebrafish embryos. We finally found that particular PG receptor signals play essential roles at least in gastrulation, vasculogenesis, and so on. We are now investigating molecular mechanisms underlying PG-induced developmental processes in zebrafish, and involvement of PGs in similar processes in mammals.
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| Free Research Field |
生化学・分子生物学
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