Planned Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
NF-κB is a critical signal transduction pathway to regulate immune and inflammatory responses, which are induced by various stimuli such as bacterial and viral infections and irradiation. We identified a novel physiological regulatory mechanism that is mediated by linearly linked ubiquitin molecules. We showed that genetic deficiency of a component of linear ubiquitin-generating enzyme (LUBAC) induces severe chronic dermatitis. Furthermore, we revealed that LUBAC activity is related with B cell lymphomas.
機能生物化学
