Planned Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Bone destruction precedes subsequent bone formation and is performed by multi-nuclear osteoclasts that differentiate from hematopoietic cells in the bone marrow. Excessive osteoclastic activity underlies osteoporosis and joint destruction associated with RA. In this study we have clarified metabolic adaptations and cell-cycle dynamics that take place during the transition from hematopoietic cells to bone-resorbing osteoclasts, and the transcriptional network involved. Further, we have identified by gene expression profiling and biochemical techniques secretory products that are released at distinct stages of osteoclastogenesis and send coupling signals to the subsequent bone formation by osteoblasts.
代謝学
