Structural basis for nuclear transport mechanism by the nuclear transport receptor and improvement of a synchrotron beamline.

2014 Fiscal Year Final Research Report

• Project Area: Structural basis of cell-signalling complexes mediating signal perception, transduction and responses
• Project/Area Number: 22121006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: YAMASHITA Eiki 大阪大学, たんぱく質研究所, 助教 (00294132)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIURA Akifumi 大阪大学, 蛋白質研究所, 特任助教 (90598129)
• Research Collaborator: YAMAZAWA Ryuji 大阪大学, 蛋白質研究所, 博士研究員 ; KOBAYASHI Takeshi 大阪大学, 大学院理学研究科 ; MATSUMOTO Ami 大阪大学, 大学院理学研究科
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 細胞構造生物 / 核-細胞質間輸送 / X線結晶構造解析 / 放射光

Outline of Final Research Achievements

Nucleocytoplasmic transport is essential for the function of eukaryotic cells. Nucleocytoplasmic transport of large molecules, including proteins and RNAs, require transport receptors. The transport receptors recognize cargo molecule and the receptor-cargo complexes are translocated through the nuclear pore complex. Here, we solved crystal structures of a transport receptor and transport receptor complex with the high accuracy measurement using a improved synchrotron beamline for the cell structural biological research.

Free Research Field

構造生物学