Establishment of neuro-vascular interactions

2015 Fiscal Year Final Research Report

• Project Area: Vasculo-neural wiring and their interdependent crosstalk
• Project/Area Number: 22122004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University (2012-2015); Nara Institute of Science and Technology (2010-2011)
• Principal Investigator: Takahashi Yoshiko 京都大学, 理学(系)研究科(研究院), 教授 (10183857)
• Co-Investigator(Kenkyū-buntansha): SAWAMOTO Kazunobu 名古屋市立大学, 大学院医学研究科, 教授 (90282350)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 血管 / 神経 / 相互作用 / ワイヤリング / 神経堤細胞 / 自律神経 / 細胞移動 / 細胞分化

Outline of Final Research Achievements

Neuro-vascular interactions have been found to play important roles in development of both neural networks and vascular networks. In particular, for the morphogenesis of neural crest cells, signals produced by the dorsal aorta are critical. In the central nervous system, the patterning of blood vessels is determined by differentiation states of neuronal cells in the spinal cord. We have also revealed a novel role of fibronectin in inter-tissue signaling. The findings obtained in this study open a new way for understanding how the neuro-vascular wiring is established and functions, which might also be applicable for other inter-tissue signaling.

Free Research Field

発生生物学