2014 Fiscal Year Final Research Report
Regulation of neuro-vascular interaction by extracellular matrix and their receptors
| Project Area | Vasculo-neural wiring and their interdependent crosstalk |
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| Project/Area Number |
22122006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 細胞外マトリックス / 基底膜 / インテグリン / 血管 / 脳・神経 |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms by which extracellular matrices regulate neuro-vascular interactions, we conducted (1) comprehensive identification of the specific ligand(s) for αVβ8 integrin, which play an important role in the formation of blood-brain barrier; and (2) functional characterization of a specialized basement membrane “fractone” in neural stem cell niche. We found that (1) TGF-β1 is the specific ligand for αVβ8 integrin, and (2) fractones are produced by neural stem cells. These results will unravel the cell-adhesive machinery that regulates the neuro-vascular interactions.
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| Free Research Field |
生物学
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