2015 Fiscal Year Final Research Report
Regulation of blood vessel-neuron interactions through ectodomain shedding of membrane proteins
| Project Area | Vasculo-neural wiring and their interdependent crosstalk |
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| Project/Area Number |
22122007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2016-03-31
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| Keywords | ADAM / エクトドメインシェディング / 神経分化 / 神経堤細胞 / 増殖因子 |
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| Outline of Final Research Achievements |
Post-mitotic neurons are generated from neural progenitor cells (NPCs) at the expense of their proliferation. We showed that post-mitotic neurons are produced only from neural progenitor cells that divide in the sub-ventricular zone (SVZ). We also showed that this neurogenesis depends on Neuregulin 1 type II (NRG1-II)-ErbB signaling. Moreover, we developed a novel fluorescent probe, which enables us to monitor the activity of the NRG1 ecotodomain shedding. Expression of the probe in zebrafish embryos revealed involvement of the NRG1 ecotodmain shedding in the spatio-temporal regulations of its signaling. We also elucidated novel roles of ADAM8 and ADAM19 in mice and ADAM12 in growth of zebrafish.
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| Free Research Field |
発生生物学、細胞生物学、分子生物学、再生医学
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