2014 Fiscal Year Final Research Report
Molecular mechanism for multipotency of stem cells
| Project Area | Neural Diversity and Neocortical Organization |
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| Project/Area Number |
22123002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 神経幹細胞 / ヒストンメチル化酵素 / ESET/Setdb1 / 分化決定因子 / Hes1 / 発現振動 |
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| Outline of Final Research Achievements |
Embryonic neural stem cells give rise to various types of neurons first and glial cells later. Thus, embryonic neural stem cells change their competency during development, but the detailed mechanism is not known. We found that in multipotent neural stem cells, multiple fate determination factors are expressed in an oscillatory manner, and that the expression of the histone methyl transferase ESET, which regulates neuronal and glial gene expression, gradually decreases during development. Because the ESET gene promoter contains multiple binding sites for Hes1, one of the fate determination factors, it was suggested that Hes1 oscillation regulates temporal changes of competency of neural stem cells via ESET expression.
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| Free Research Field |
分子生物学
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