2014 Fiscal Year Final Research Report
Mechanisms of neurogenesis and gliogenesis by neural stem cells
| Project Area | Neural Diversity and Neocortical Organization |
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| Project/Area Number |
22123004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 神経幹細胞 / 神経細胞 / グリア / 分化 / 転写因子 / Coup-TFI/II / miRNA / p38MAP-kinase |
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| Outline of Final Research Achievements |
We have explored novel factors which are integrated in the molecular machinery responsible for neurogenic-to-gliogenic transition of neural stem cells (NSCs) downstream of and in parallel with transcription factors Coup-TFI/II which are triggers of this transition. 1) We identified a miRNA family miR-17/106 as novel key regulators of the transition through downregulation of p38 MAP-Kinase downstream of Coup-TFI/II. 2) We found that the miR-153 mediated fine control of expressions of NFIA/B which are essential for gliogenesis is important in the molecular networks that regulate the timing of gliogenesis by NSCs in the developing CNS.
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| Free Research Field |
発生生物学
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