2015 Fiscal Year Final Research Report
General principles determinating organ-level regenerative capacity in vertebrates
| Project Area | Molecular mechanisms underlying reconstruction of 3D structers during regeneration |
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| Project/Area Number |
22124005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hirosaki University (2013, 2015)
Tohoku University (2010-2012, 2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Koji 東北大学, 大学院生命科学研究科, 教授 (70261550)
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| Project Period (FY) |
2010-04-01 – 2016-03-31
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| Keywords | 再生 / 四肢 / 皮膚 / 遺伝子操作 / 両生類 |
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| Outline of Final Research Achievements |
We aimed to reveal common principles of organ-level regeneration among animals by using Xenopus as the main model. Firstly, we focused on the anterior-posterior axis formation of a limb and elucidated the avian digit identity of fore- and hindlimb. We found that an adult (metamorphosed) Xenopus can regenerate its skin almost completely after deep injury while an adult mammal cannot regenerate its skin. We analyzed the function of Hippo signaling pathway in organ regeneration of Xenopus and provided evidence that underlies the common mechanism(s) among vertebrate and invertebrate animals. We also found that epigenetic modification of genome is stable during limb regeneration by genome-wide analysis of histone modification. We also developed new experimental techniques for local gene induction in amphibians.
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| Free Research Field |
再生生物学、発生生物学
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