Adaptation in the structure and function of the chromosomes that ensures genome transmission across generations

2014 Fiscal Year Final Research Report

• Project Area: Systematic study of chromosome adaptation
• Project/Area Number: 22125004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: ISHII Kojiro 大阪大学, 生命機能研究科, 特任准教授 (40360276)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ゲノム / 染色体 / セントロメア / テロメア

Outline of Final Research Achievements

Here we investigated the molecular mechanisms of chromosomal reorganization occurred to our previously-developed model chromosome system in fission yeast that recapitulates the spontaneous adaptation response toward a collapse of genome transmission function in the chromosomes. Through this study, we uncovered that the eukaryotic chromosomal termini are generally advantageous in producing flexible and adaptive chromosomal responses to achieve preservation of entire genome contents, and that the centromeres are newly established at ectopic positions in a stepwise manner allowing diverse and elastic ways of their functional maturation to fit to the local chromosomal environment.

Free Research Field

分子生物学