Role of stress-induced epigenetic change in genome adaptation

2014 Fiscal Year Final Research Report

• Project Area: Systematic study of chromosome adaptation
• Project/Area Number: 22125005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ISHII Shunsuke 独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: エピゲノム / 遺伝 / ストレス / 環境要因

Outline of Final Research Achievements

It was shown that transcription factor ATF-2 mediates the heat shock stress-induced epigenetic change which is transmitted to next generation. The ATF-2 family transcription factors are also involved in the innate immune memory and the psychological stress-induced telmere shortening. Furthermore, they mediates the epigenome change induced by nutritional condition and psychological stress which are transmitted to next generation. Thus, ATF-2 family transcription afctors contribute to the epigenome change induced by various environmental factors and its inheritance.

Free Research Field

生物学