2014 Fiscal Year Final Research Report
Study of the occurrence of mutations and adaptive genome evolution via genomic analyses
| Project Area | Systematic study of chromosome adaptation |
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| Project/Area Number |
22125009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYANAGI Kanako 北海道大学, 大学院情報科学研究科, 准教授 (20362840)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 突然変異 / 組換え / 修復 / ゲノム / 進化 / 自然選択 |
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| Outline of Final Research Achievements |
In order to obtain the fundamental properties of occurrence of genomic mutations so as to identify genomic changes that have led to adaptive evolution, i.e., genome adaptation, via finding significant deviations from the expectations calculated with the properties of the occurrence of mutations, we artificially introduced random double-strand breaks (DSBs) to the budding yeast genome and detected occurred mutations during repair of the DSBs by sequencing the whole genomes. In addition, we have computationally traced back genomic changes of natural human adenoviruses (HAdV), and it was suggested that HAdVs have changed via homologous recombination events between distant relatives. The statistical properties of this type of changes in HAdV indicate that the recombinant forms have been selected for adaptation.
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| Free Research Field |
比較ゲノム学
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