Search for novel bioactive peptides that concern in the lipid storage and appetite regulation in various species.

2014 Fiscal Year Final Research Report

• Project Area: Molecular Basis and Disorders of Control of Apetite and Fat Accumulation
• Project/Area Number: 22126003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kurume University
• Principal Investigator: KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
• Co-Investigator(Renkei-kenkyūsha): SATO Takahiro 久留米大学, 分子生命科学研究所, 准教授 (50368883) ; SANO Hiroko 久留米大学, 分子生命科学研究所, 講師 (90506908) ; IDA Takanori 宮崎大学, フロンティア科学実験総合センター, 准教授 (00381088)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 脂肪組織 / オーファン受容体 / 生理活性ペプチド / 摂食調節ペプチド / GPCR / ショウジョウバエ / 脂肪体 / インスリン様ペプチド

Outline of Final Research Achievements

We used drosophila orphan GPCRs to find novel endogenous ligands. We chose the target GPCRs, which are homologous receptors to appetite regulating GPCRs in mammals. Consequently, we succeeded to discover five novel bioactive peptides of three categories: CCHamide-1 and -2, dRYamide-1 and -2, and trissin.
We studied about CCHamide-2 and found that it was highly expressed in the drosophila fat body, which corresponds to the mammalian adipose tissue. Moreover, CCHamide-2 is secreted from the fat body and acts on insulin-like peptide producing cells in the drosophila brain to stimulate secretions of insulin-like peptides.

Free Research Field

内分泌学、生化学