2014 Fiscal Year Final Research Report
Brain mechanism for energy sensing and food preference.
| Project Area | Molecular Basis and Disorders of Control of Apetite and Fat Accumulation |
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| Project/Area Number |
22126005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Shiki 生理学研究所, 発達生理学研究系, 助教 (40342919)
SHIUCHI Tetsuya 生理学研究所, 発達生理学研究系, 助教 (70372729)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 摂食行動 / 視床下部 / AMPK |
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| Outline of Final Research Achievements |
Food selection, which is essential to maintain metabolic homeostasis, is modulated by nutritional state, food palatability and social life events such as stress. Here we show that AMP-activated protein kinase (AMPK) in a subset of corticotropin-releasing hormone (CRH) positive neurons in the paraventricular hypothalamus (PVH) regulates selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) in mice after fasting. Activation of AMPK in these CRH neurons was necessary and sufficient for mice to increase selection of a HCD and reduce that of a HFD. Our results thus provide important insight into the regulation of food selection behavior under physiological and pathological conditions.
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| Free Research Field |
生理学
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