2014 Fiscal Year Final Research Report
The pathophysiological role of bioactive peptides regulating energy metabolism against obesity
| Project Area | Molecular Basis and Disorders of Control of Apetite and Fat Accumulation |
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| Project/Area Number |
22126009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIDEKI Yamaguchi 宮崎大学, 医学部, 講師 (10305097)
HIROAKI Ueno 宮崎大学, 医学部, 助教 (00381062)
KOJI Toshinai 宮崎大学, 医学部, 講師 (80381101)
HIRONOBU Tsubouchi 宮崎大学, 医学部, 助教 (60573988)
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| Co-Investigator(Renkei-kenkyūsha) |
AKIKO Taguchi 国立研究開発法人国立長寿医療研究センター, 部長 (80517186)
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| Research Collaborator |
Waise Zaved T.M
Naznin Farhana
Moin Abu Saleh MD
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 内科 / 医療 / 生理活性 / 糖尿病 / トランスレーショナルリサーチ / 肥満 / インスリン分泌 / 膵β細胞 |
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| Outline of Final Research Achievements |
The vagus nerve links between the visceral organs and central nervous system (CNS). Here we showed that mice fed high-fat diet (HFD) developed acute inflammatory responses in the distal colon then the inflammation was induced in the nodose ganglion and hypothalamus through the vagus afferent nerve. These inflammations in the CNS induced the disorder of autonomic efferent nerve and immune system to cause hyperphasia and obesity. Because only one day HFD induced inflammation in the CNS, it is important to reduce fat intake for prevention of obesity.
We identified a novel peptide that is coexpressed with insulin in the secretory granules of pancreatic β cells. This peptide enhanced glucose-induced insulin secretion both in vitro and in vivo and this effect was mediated by increasing intracellular Ca2+ influx in β cells. These findings will provide a new candidate for insulin secretagogues and peptide-based therapeutics for type 2 diabetes.
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| Free Research Field |
内分泌
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