2014 Fiscal Year Final Research Report
Mechanism of failure of appetite regulating system in obesity
| Project Area | Molecular Basis and Disorders of Control of Apetite and Fat Accumulation |
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| Project/Area Number |
22126010
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | International University of Health and Welfare (2013-2014)
Takasaki University of Health and Welfare (2012)
Kiryu University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSAKI Aya 群馬大学, 医学部附属病院, 医員 (30711387)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Takafumi 獨協医科大学, 越谷分院, 講師 (20396659)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | ネスファチン |
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| Outline of Final Research Achievements |
The present study used Nesf (nesfatin) transgenic (Tg) mice to investigate the metabolic role of Nesf. No differences were observed in daily food intake and body weight. Nesf Tg mice showed decreased mRNA expression of CART. Nesf Tg mice fed 45% high-fat diet (HFD) showed higher increase in body weight than their non-Tg littermates; however, no difference was observed in daily food intake between these 2 groups. Nesf Tg mice fed 45% HFD showed a significant increase in the weight of the liver, subcutaneous fat, and brown adipose tissue and decrease in the expression of uncoupling protein-1 in the subcutaneous fat. Insulin levels of these Tg mice were significantly higher. Histological analysis showed marked fat deposition in the hepatocytes surrounding the hepatic central veins in Nesf/NUCB2 Tg mice fed 45% HFD. It is indicated that Nesf/NUCB2 is involved in the development of insulin resistance and fat deposition in the liver, independent of the modulation of energy intake.
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| Free Research Field |
肥満
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