2014 Fiscal Year Final Research Report
A ligical link between force-sensitivec process in a micro sclae and cardiogenesis in a macro level.
| Project Area | From molecules, cells to organs : trans-hierarchical logic for higher-order pattern and structures |
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| Project/Area Number |
22127006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 力刺激 / 転写調節 / miRNA / 心臓発生 / 弁形成 |
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| Outline of Final Research Achievements |
Heart does not develop normally without physical stimuli generated by heartbeat and circulation of blood. In fact, when heart contracts abnormally and/or blood circulates in a disturbed way, cardiac anomalies develop in both mouse and zebrafish. Onset of congenital heart diseases in human is believed to have the same mechanical background as other experimental model animals. Nonetheless, molecular mechanism by which cardic cells sense physical forces generated contraction and blood flow is largely unknown. To establish a solid logical link between force and heart development, we performed this project and found key factors that play important roles during the force-sensitive process of cardiogenesis. More importantly, we revealed a molecular mechanism underlying the force-induced gene expression. As an unexpected results, we have fond this force-sensitive process regulates other biological phenomena, such as metabolic homeostasis and regeneration/wound healing.
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| Free Research Field |
分子生物学、発生生物学
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