Analysis of Niche Regulation for Cancer Stem Cells

2014 Fiscal Year Final Research Report

• Project Area: Development of Novel Treatment Strategies Targeting Cancer Stem Cells
• Project/Area Number: 22130004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Keio University
• Principal Investigator: TOSHIO Suda 慶應義塾大学, 医学部, 教授 (60118453)
• Co-Investigator(Kenkyū-buntansha): TAKUBO Keiyo 慶應義塾大学, 医学部, 専任講師 (50502788) ; NAGAMATSU Go 九州大学, 医学(系)研究科(研究院), 助教 (70453545) ; IKUSHIMA Yoshiko 独立行政法人国際医療研究センター, その他部局等, 上級研究員 (00571366)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 癌幹細胞 / ニッチ / 活性酸素 / 血液腫瘍疾患 / 細胞周期

Outline of Final Research Achievements

Stem cell maintenance in a haltered cell-cycle state (i.e., quiescence) has been proposed as a fundamental property of HSCs. Maintenance of quiescence protects HSCs from functional exhaustion and naturally producing extrinsic cellular insults to enable lifelong hematopoietic cell production. HSC quiescence is regulated through a complex network of cell intrinsic regulations along with extrinsic influences from the microenvironment. Normal HSCs maintain intracellular hypoxia, stabilize the hypoxia-inducible factor-1α (HIF-1α) protein and generate ATP by anaerobic metabolism. In HIF-1α deficiency, HSCs became metabolically aerobic, lost cell cycle quiescence, and finally exhausted.

Free Research Field

幹細胞生物学