2014 Fiscal Year Final Research Report
sex differences regulated by W- and Y-sex chromosomes
| Project Area | Molecular mechanisms for establishment of sex differences. |
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| Project/Area Number |
22132003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Kei 北里大学, 理学部, 助教 (50458767)
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| Research Collaborator |
SHIBATA Yasushi
TAKAMATSU Nobuhiko
MAWARIBUCHI Shuuji
FUJITANI Kazuko
IKEDA Nozomi
OTOMO Asako
WADA Mikako
MUSASHIJIMA Masato
NAKASAKO Kei
OKANO Norihito
OHASHI Shuntaro
KAMATA Yosuke
MURATA Eriko
NOGAMI Asuka
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 性決定 / 性分化 / 性染色体 / 雄駆動進化 / プロモーター / 性ホルモン / アフリカツメガエル / 転写因子 |
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| Outline of Final Research Achievements |
We examined sex-determining and -differentiating mechanisms in various vertebrate species including African clawed frogs Xenopus laevis, sand lamprey, leopard gecko, mouse, and teleost fish medaka, and obtained the following conclusion. 1. DM-W may be a sex (female)-determining gene as an anti-testis forming gene in X. laevis. 2. Dmrt1 got another promoter within the first intron for masculinization of somatic cells during vertebrate evolution. 3. We discovered the ‘mass-in-line’ structure in X. laevis, of which analysis suggests that the default sex is female in the species. 4. Undifferentiated sex chromosomes easily allow replacement of a sex-determining gene with another new one. 5. Meiotic recombination counteracts male-biased mutation (male-driven evolution).
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| Free Research Field |
分子発生進化学
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