Studies on molecular mechanisms of sexual differenciation based on genome informatics approach

2014 Fiscal Year Final Research Report

• Project Area: Molecular mechanisms for establishment of sex differences.
• Project/Area Number: 22132005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University (2012-2014); Kyoto University (2010-2011)
• Principal Investigator: SUYAMA Mikita 九州大学, 生体防御医学研究所, 教授 (70452365)
• Co-Investigator(Renkei-kenkyūsha): UCHIYAMA Ikuo 基礎生物学研究所, 理論生物学領域, 助教 (90243089)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 比較ゲノム / バイオインフォマティクス / 遺伝子発現制御 / シス因子

Outline of Final Research Achievements

Comparative genomics and epigenomic analyses have rapidly been developed with the technological progress of next-generation sequencing platforms. These high-throughput genome analysis tools enabled us to conduct studies focusing on some of the fundamental biological processed such as sexial differenciation in molecular levels. The major objective of our research was to comprehensively reveal gene regulation associated with the process in genome-wide fashion. We reveals that there is sexially different expression of genes even in somatic cells. We also elucidated a molecular mechanisms behind decidualization of endometrial stromal cells by a genome-wide gene expression analysis combined with the data from epigenetic changes. During this project, we have also developed some computational methodologies useful for general analyses in the field of molecular biology and medicine.

Free Research Field

比較ゲノム