2014 Fiscal Year Final Research Report
Analysis of HLA class I/II binding peptides and binding motifs and its application for cancer immunotherapy
| Project Area | HLA polymorphism, disease and evolution |
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| Project/Area Number |
22133005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IRIE Atsushi 熊本大学, 大学院生命科学研究部, 講師 (30250343)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | がん免疫療法 / がん抗原 / ペプチドワクチン / キラーＴ細胞 / ヘルパーＴ細胞 |
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| Outline of Final Research Achievements |
Two tumor-associated antigens, KIF20A- and GPC3-derived long peptides (LPs) that can be presented to CD4+ type 1 T helper (Th1) cells through multiple HLA class II molecules frequently observed in the Japanese population were identified. Using HLA-A2/A24-transgenic mice, vaccination of those LPs encompassing short peptides (SPs) that can activate the tumor-reactive cytotoxic T lymphocytes (CTL) more efficiently induced CTLs than SP-vaccination did, suggesting the effectiveness of LPs for the improvement of anti-tumor immunotherapy. In addition, it was observed that among the patients vaccinated several times with SP derived from GPC3, an oncofetal tumor-associated antigen highly and frequently expressed in the hapatocellular carcinoma, those who induced Th cell responses specific to GPC3-LPs exhibited significantly longer overall survival time.
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| Free Research Field |
腫瘍免疫学
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