Variation and disease associations of HLA genes

2014 Fiscal Year Final Research Report

• Project Area: HLA polymorphism, disease and evolution
• Project/Area Number: 22133008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TOKUNAGA KATSUSHI 東京大学, 医学(系)研究科(研究院), 教授 (40163977)
• Co-Investigator(Kenkyū-buntansha): MIYAGAWA Taku 東京大学, 大学院医学系研究科, 助教 (20512263) ; HONDA Makoto 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (50370979)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: HLA / 病因遺伝子 / ナルコレプシー / 自己免疫疾患 / 感染症 / 肝炎 / 原発性胆汁性肝硬変

Outline of Final Research Achievements

By means of genome-wide association studies (GWAS) and comprehensive analyses of HLA gene polymorphisms, linkage disequilibrium and haplotypes, a number of HLA and non-HLA susceptibility gene variants have been identified for various immune-mediated diseases including narcolepsy, hepatitis B and C virus-related diseases, type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and Stevens-Johnson syndrome. Possible interactions between the susceptibility variants were also analyzed. The findings contribute to the elucidation of pathogenic mechanisms of these diseases.

Free Research Field

人類遺伝学