Genetic and immunological analysis for HLA-DP5 and HLA-DR53 related diseases.

2014 Fiscal Year Final Research Report

• Project Area: HLA polymorphism, disease and evolution
• Project/Area Number: 22133009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: SASAZUKI Takehiko 九州大学, 生体防御医学研究所, 特別主幹教授 (50014121)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Tadashi 独立行政法人国立国際医療研究センター, 研究所, 室長 (00333790) ; TANAKA Yoshihiko 福岡歯科大学, 歯学部, 教授 (00398083) ; KISHIKAWA Reiko 独立行政法人国立病院機構福岡病院(臨床研究部), アレルギー科, 医長 (50450945) ; MORI Akio 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 部長 (80251247) ; OKAMURA Ken 九州大学, 医学研究院, 名誉教授 (90150432) ; YOSHIKAI Yasunobu 九州大学, 生体防御医学研究所, 教授 (90158402) ; NODA Mitsuhiko 独立行政法人国立国際医療研究センター, 糖尿病研究部, 部長 (90237850)
• Research Collaborator: ITO Kouichi ; YOSHIMURA Hiroshi
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ＨＬＡ－ＤＰ５ / ＨＬＡ－ＤＲ５３ / グレーブス病 / 橋本病 / スギ花粉症 / ＨＬＡ立体構造 / エピスターシス / ゲノム解析

Outline of Final Research Achievements

We identified Graves disease-specific susceptible HLA alleles, HLA-DR14:03 and DPB1*05:01, and protective alleles, HLA-DRB1*13:02, DRB1*15:02 and B*07:02 by association analysis for HLA-A, B, C, DRB1, DQB1 and DPB1 loci. In addition, we elucidated the epistatic role of protective HLA-DRB1*13:02 allele to susceptible HLA alleles in the incidence of Graves disease. We revealed a crystal structure of the CryJ-1-derived peptide, a major allergen of cedar pollinosis, and HLA-DP5 complex, which would contribute to development of a chemical compound capable of regulating the allergic reaction.

Free Research Field

免疫遺伝学・人類遺伝学