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2014 Fiscal Year Final Research Report

Genetic and immunological analysis for HLA-DP5 and HLA-DR53 related diseases.

Planned Research

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Project AreaHLA polymorphism, disease and evolution
Project/Area Number 22133009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

SASAZUKI Takehiko  九州大学, 生体防御医学研究所, 特別主幹教授 (50014121)

Co-Investigator(Kenkyū-buntansha) OKAMURA Tadashi  独立行政法人国立国際医療研究センター, 研究所, 室長 (00333790)
TANAKA Yoshihiko  福岡歯科大学, 歯学部, 教授 (00398083)
KISHIKAWA Reiko  独立行政法人国立病院機構福岡病院(臨床研究部), アレルギー科, 医長 (50450945)
MORI Akio  独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 部長 (80251247)
OKAMURA Ken  九州大学, 医学研究院, 名誉教授 (90150432)
YOSHIKAI Yasunobu  九州大学, 生体防御医学研究所, 教授 (90158402)
NODA Mitsuhiko  独立行政法人国立国際医療研究センター, 糖尿病研究部, 部長 (90237850)
Research Collaborator ITO Kouichi  
YOSHIMURA Hiroshi  
Project Period (FY) 2010-04-01 – 2015-03-31
KeywordsHLA-DP5 / HLA-DR53 / グレーブス病 / 橋本病 / スギ花粉症 / HLA立体構造 / エピスターシス / ゲノム解析
Outline of Final Research Achievements

We identified Graves disease-specific susceptible HLA alleles, HLA-DR14:03 and DPB1*05:01, and protective alleles, HLA-DRB1*13:02, DRB1*15:02 and B*07:02 by association analysis for HLA-A, B, C, DRB1, DQB1 and DPB1 loci. In addition, we elucidated the epistatic role of protective HLA-DRB1*13:02 allele to susceptible HLA alleles in the incidence of Graves disease. We revealed a crystal structure of the CryJ-1-derived peptide, a major allergen of cedar pollinosis, and HLA-DP5 complex, which would contribute to development of a chemical compound capable of regulating the allergic reaction.

Free Research Field

免疫遺伝学・人類遺伝学

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Published: 2016-06-03  

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