Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We tried to identify the therapeutic targets and biomarkers of uncharacterized chemical compound by genomics analysis of the resistant sub-clone cells and functional genomics screening. We also established the antigen receptor repertoire analysis technology of tumor infiltrating lymphocytes for biomarker discovery of the cancer immunotherapy. For diffuse-type gastric cancer, where the valid molecular target is absent, we performed the whole exome sequencing and have identified RHOA driver gene mutations as potential therapeutic targets.
Attribution of KAKENHI