2014 Fiscal Year Final Research Report
| Project Area | Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention |
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| Project/Area Number |
22134006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Kyoto University (2013-2014)
The University of Tokyo (2010-2012) |
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Principal Investigator |
SEISHI ogawa 京都大学, 医学(系)研究科(研究院), 教授 (60292900)
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| Co-Investigator(Renkei-kenkyūsha) |
SANADA Masashi 名古屋医療センター, 部長 (20529044)
SATO Aiko (MATSUBARA Aiko) 京都大学, 大学院医学研究科, 研究員 (70512573)
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
SAKATA Mamiko (YANAGIMOTO Mamiko) 筑波大学, 医学医療系, 准教授 (80451805)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | がんゲノム / SNPアレイ / リシーケンス / 癌の個性 / 分子標的 / 白血病 / 造血幹細胞 / 造血器腫瘍 |
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| Outline of Final Research Achievements |
Cancer is caused by genetic abnormalities, which cause alterations in characteristics of cells, leading to deregulated proliferation of abnormal cells, where the difference in genetic alterations defines heterogeneity of cancer in different individuals. In this study, we have comprehensively investigated genetic alterations in a variety of cancers, including myelodysplastic syndromes (MDS), Down syndrome-related myeloproliferative neoplasm, clear cell renal carcinoma (ccRCC), lower-grade gliomas. Through these studies, we delineated the entire pictures of these cancers, newly identifying mutational targets that characterize each tumor types, including RNA splicing factors, the cohesin complex in MDS, mTOR and TCEB1 in ccRCC and many other genes plausible for drug targets. Our findings will contribute to the development of novel diagnostics and therapeutics.
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| Free Research Field |
血液内科学
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