Continued development of a comprehensive computational platform for Systems Biology

2014 Fiscal Year Final Research Report

• Project Area: Establishment of Integrative Multi-level Systems Biology and its Applications
• Project/Area Number: 22136003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Okinawa Institute of Science and Technology Graduate University
• Principal Investigator: KITANO Hiroaki 沖縄科学技術大学院大学, 統合オープンシステムユニット, 教授 (80500256)
• Research Collaborator: MATSUOKA Yukiko システムバイオロジー研究機構, シニアリサーチャー ; GHOSH Samik システムバイオロジー研究機構, シニアリサーチャー
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: シグナル伝達 / ゲノム / 情報工学 / シミュレーション工学 / 循環器

Outline of Final Research Achievements

Development of the project-wide software platform is the mission of the group. Based on cellular level modeling that is relatively well established, we have expanded our platform to be able to create multi-scale physiological model for drug effect predictions. PhysioDesigner modeling software, PHML description language, and Flint simulation core have been developed and widely distributed. In parallel, we have delved into molecular interactions for broad-coverage high precision docking simulation using machine learning and parallel execution of multiple docking strategies. Furthermore, Garuda alliance was formed and the official version of Garuda Platform was released, and now widely used by pharmaceutical companies. Combined together, we have accomplished our initial commitment of platform development, and we consider it is very successful.

Free Research Field

システムバイオロジー