Integration of the regulation of cardiac myocyte signal pathway and neuro hormonal regulation

2014 Fiscal Year Final Research Report

• Project Area: Establishment of Integrative Multi-level Systems Biology and its Applications
• Project/Area Number: 22136009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA YOSHIHIRO 横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): AKAHANE Satomi 東邦大学, 医学部, 教授 (00184185) ; SATO Motohiko 横浜市立大学, 医学部, 准教授 (40292122) ; FUJITA Takayuki 横浜市立大学, 医学部, 講師 (40468202) ; OKUMURA Satoshi 鶴見大学, 歯学部, 教授 (60233475)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: シグナル伝達 / 生理学 / 循環器・高血圧

Outline of Final Research Achievements

Sympathetic regulation of the heart occurs via adenylyl cyclase that produces cAMP, and is stimulated by catecholamine receptors. Cyclic AMP activates its downstream enzymes and phosphorylates various intracellular molecules while its major target is the L-type calcium channel. This channel increases the influx of calcium into cells and regulate the contractility of cardiac myocytes. Because the influx of calcium changes upon cardiac beating, relationship between adenylyl cyclase activity and calcium channel activity may simultaneously change upon beating. We thereby investigated the relationship between the two system based upon our previous understanding. We also found that there is a mutual regulation between adenylyl cyclase and calcium channel activity which is based upon space and time considerations. This understanding is also useful to predict the occurrence of cardiac arrhythmic events.

Free Research Field

循環器病学