Analyses of small molecules behaviors in the body which is emerged by the cooperation of multi-organs.

2014 Fiscal Year Final Research Report

• Project Area: Establishment of Integrative Multi-level Systems Biology and its Applications
• Project/Area Number: 22136015
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: SUZUKI Hiroshi 東京大学, 医学部附属病院, 教授 (80206523)
• Co-Investigator(Renkei-kenkyūsha): HONMA Masashi 東京大学, 医学部附属病院, 特任准教授 (60401072) ; TAKADA Tappei 東京大学, 医学部附属病院, 講師 (90376468)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 生理学 / 情報工学 / 生体分子 / 発現制御 / 生体反応性

Outline of Final Research Achievements

Homeostasis for blood concentrations of various small molecules is one of the most important mechanisms to maintain life. In the present study, we focused on this system which is emerged by the cooperation of multi-organs, aiming to achieve the integrated comprehension of the systems behaviors. In the first half of the study period, we have built novel mathematical models to describe the behavior of small molecules in the body, using drug molecules as models. In the second half of the study, we extended the target ranges to various endogenous small molecules, including highly lipophilic compounds such as cholesterol and fat-soluble vitamins, inorganic salts such as phosphate and calcium, and urate. We have elucidated molecular mechanisms for regulating the behavior of these compounds in the body, and have integrated the information to the multi-organ models.

Free Research Field

臨床薬物動態学