2015 Fiscal Year Final Research Report
Search for medicinal seeds and analysis of their target molecules
| Project Area | Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity |
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| Project/Area Number |
23102005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Masayoshi 大阪大学, 大学院薬学研究科, 准教授 (80311231)
KOTOKU Naoyuki 大阪大学, 大学院薬学研究科, 助教 (20362618)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ケミカルバイオロジー / 活性天然物 / 海洋薬物資源 / 標的分子 / 医薬シーズ |
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| Outline of Final Research Achievements |
On the guidance of the constructed screening systems for searching anti-cancer and anti-tuberculosis substances from the extract library of marine medicinal resources, we succeeded in the isolation of several bioactive natural products, which are expected to be medicinal seeds. We then engaged in the total synthesis and analog synthesis of the bioactive natural products to supply sufficient amount for further biological analysis and structure-activity relationship study.
Furthermore, we explored new methods to promote the generality of the method for identifying target molecule of bioactive compound. Through the target identification study of the isolated bioactive natural products by using the designed new probe molecules, the Mycobacterium transformed with a genomic DNA library, and the phage display method, we could clarify the several responsible molecules expected as new drug targets for Cancer and Tuberculosis.
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| Free Research Field |
天然物化学
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