2015 Fiscal Year Final Research Report
Study toward Development Ionotropic Glutamate Receptore Subytpe Selective Ligand
Project Area | Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity |
Project/Area Number |
23102009
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Science and Engineering
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Research Institution | Osaka City University |
Principal Investigator |
Shianda Tetsuro 大阪市立大学, 大学院理学研究科, 教授 (30271513)
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Co-Investigator(Kenkyū-buntansha) |
Ohfune Yasufumi 大阪市立大学, 大学院理学研究科, 名誉教授 (20142078)
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Co-Investigator(Renkei-kenkyūsha) |
Shimamoto Keiko (公益財団法人)サントリー生命科学財団, 主幹研究員 (70235638)
Sakaguchi Kazuhiko 大阪市立大学, 大学院理学研究科, 准教授 (80264795)
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Project Period (FY) |
2011-04-01 – 2016-03-31
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Keywords | グルタミン酸受容体 / 天然物 / カイトセファリン / アクロメリン酸 / リガンド / 超活性 |
Outline of Final Research Achievements |
Chemical biology of natural products focusing on naturally occurring ionotropic glutamte receptor ligands, acromelic acid A and kaitocephalin was studied. Studies involving total synthesis of these natural products, their analog synthesis, ionotropic glutamate receptor binding assay, and structure analysis of ligand-protein complexes of these natural products bound to ionotropic glutamate receptors were conducted. As a result, the target receptor subtype of kaitocephalin was identified. Moreover, (7S)-kaitocephalin was discovered as a more potent NMDA receptor selective ligand than kaitocephalin.
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Free Research Field |
ケミカルバイオロジー
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