• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Mode-of-action of endogenous factor controlling biological phenomena

Planned Research

  • PDF
Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 23102012
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

UEDA Minoru  東北大学, 理学研究科, 教授 (60265931)

Project Period (FY) 2011-04-01 – 2016-03-31
Keywords天然物リガンド / コロナチン / 立体異性体
Outline of Final Research Achievements

Our most important achievement is to show that a stereoisomer of natural products is most useful for tuning the target selectivity. Usually, natural product have plural target and functions as a multi-biofunctional molecule. natural product behave like a bunch of keys, not a canonical lock-and-key. We can reduce the side reactions in the body by using a stereoisomer of natural products. We demonstrated the successful example of target tuning of natural products in plant hormone mimicking natural product, coronatine.

Free Research Field

天然物有機化学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi