Planned Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
The third-generation small-molecule affinity matrix has been developed to facilitate target protein identification of bioactive small molecules. This newly developed photoactivatable and photocleavable affinity matrix enabled quantification of the amount and distribution of immobilized small molecules prior to the pull-down experiments to identify target protein for the immobilized small molecules. We also performed structure-activity relationship studies and target identification studies of bioactive natural products such as cytotoxic macrolactam natural products heronamides and vicenistatin, cytotoxic macrolide FD-891, osteoclastogenesis inhibitor methyl gerfelin, and anticancer polyketides irciniastatins.
ケミカルバイオロジー
