2015 Fiscal Year Final Research Report
Control of ion-channel functions by analogues of natural toxins
| Project Area | Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity |
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| Project/Area Number |
23102015
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Konoki Kei-ichi 東北大学, 大学院農学研究科, 准教授 (40292825)
Adachi Masaatsu 名古屋大学, 大学院生命農学研究科, 助教 (80432251)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | テトロドトキシン / サキシトキシン / 阻害剤 / 電位依存性ナトリウムチャネル / サブタイプ選択性 |
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| Outline of Final Research Achievements |
Tetrodotoxin, a puffer fish toxin, inhibits voltage-gated sodium channel (VSGC), a key protein of neurotransmission, however, dose not show subtype selectivity. Purpose of this research is to find a new subtype selective inhibitor of VGSCs, by synthesizing a dozen analogues of TTX. However, slight modification of TTX decreases the inhibitory activity of VGSC. On the other hand, we found that crambesin B carboxylic acid, a marine natural product, exhibits potent inhibition comparable to TTX for the first time.
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| Free Research Field |
天然物合成
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