Fine Synthetic Design by Rare Metal-Free Coupling Reactions

2015 Fiscal Year Final Research Report

• Project Area: Advanced Molecular Transformations by Organocatalysts
• Project/Area Number: 23105006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Ritsumeikan University
• Principal Investigator: Kita Yasuyuki 立命館大学, 総合科学技術研究機構, 教授 (00028862)
• Co-Investigator(Kenkyū-buntansha): DOHI TOSHIFUMI 立命館大学, 薬学部, 准教授 (50423116)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 創薬合成

Outline of Final Research Achievements

Our research objectives in this project mainly focus on the development of novel molecular transformations for environmentally benign and asymmetric reactions aiming at fine chemicals and related compounds using hypervalent iodine reagents. As one of the major achievements, a series of new metal-free oxidative coupling strategies for effecting C-H functionalizations as well as direct cross-couplings between two C-H bonds of different aromatics has been established. We have also succeeded in realization of highly efficient iodine catalyzed asymmetric reactions by designing new chiral iodine catalysts as asymmetric organocatalysts.

Free Research Field

有機合成化学