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2015 Fiscal Year Final Research Report

Regioselective Functionalization by Organocatalysis

Planned Research

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Project AreaAdvanced Molecular Transformations by Organocatalysts
Project/Area Number 23105008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

Kawabata Takeo  京都大学, 化学研究所, 教授 (50214680)

Project Period (FY) 2011-04-01 – 2016-03-31
Keywords有機分子触媒 / 位置選択性 / アシル化 / 配糖体天然物 / 晩期官能基化 / 超分子キラリティー / 遠隔位不斉誘導 / 触媒制御
Outline of Final Research Achievements

Regioselective manipulation of one of the multiple hydroxy groups of polyols such as carbohydrates has been a fundamental challenge in current organic synthesis. We have developed the following conventionally difficult molecular transformations; (1) total Synthesis of natural glycosides via catalytic regioselective acylation of carbohydrates, (2) organocatalytic late-stage functionalization of a natural cardiac glycoside, lanatoside C, (3) chemoselective oxidation by electronically tuned nitroxyl radical catalysts, (4) asymmetric desymmetrization of σ-symmetric linear diols, (5) kinetic resolution of a topologically chiral racemic rotaxane, (6) catalyst-controlled regiodivergent vinylogous aza-Morita-Baylis-Hillman reactions.

Free Research Field

有機分子触媒

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Published: 2017-05-10  

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