Development of Molecular Transforming System Using Organocatalytic Aromatic Deprotonation

2015 Fiscal Year Final Research Report

• Project Area: Advanced Molecular Transformations by Organocatalysts
• Project/Area Number: 23105009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: Kondo Yoshinori 東北大学, 薬学研究科(研究院), 教授 (90162122)
• Research Collaborator: TANAKA Yoshiyuki 徳島文理大学, 薬学部, 教授 ; INAMOTO Kiyofumi 武庫川女子大学, 薬学部, 准教授 ; KUMADA Kanako 東北大学, 大学院薬学研究科, 助手
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 有機分子触媒 / 脱プロトン化 / 芳香環 / 芳香族複素環 / アミド塩基 / C-H修飾反応 / メタルフリー

Outline of Final Research Achievements

Arenes and heteroarenes have been widely used in the structure of various drug candidates. The development of new methodology for the C-H functionalization of aromatic molecules is considered to be one of the most important subjects in medicinal oriented organic synthesis. Many kind of transition metalcatalyzed reactions have been employed for the selective modification of aromatic molecules, but the comtamination of heavy metals in the precursors of drug syntheses is strictly regulated. In this project, develpment of organocatalytic systems for selective C-H functionalization of aromatic molecules was investigated without using transition metal catalyzed processes. Especially, new deprotonative functionalizations were achieved by using in situ generated amide base catalyst.

Free Research Field

有機反応化学