2015 Fiscal Year Final Research Report
Eco-benign Synthesis of Versatile Chiral Building Blocks Driven by Organocatalysis
| Project Area | Advanced Molecular Transformations by Organocatalysts |
|---|
| Project/Area Number |
23105011
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Keywords | 有機触媒 / 酸化触媒 / 不斉触媒 / 合成素子 / 不斉合成 / 環境調和 |
|---|
| Outline of Final Research Achievements |
Natural products having a fused seven membered ring often elicit fascinating biological activities and pose considerable challenges to synthetic community. In order to enrich the strategic latitude for assembling medicinally relevant cycloheptanoid and hydroazulenoid structures, we have developed enantioselective routes to versatile cycloheptanoid chiral building block, namely, 4-hydroxy-cyclohept-2-en-1-one and 8-oxabicyclo[3.2.1]oct-3-en-2-one, driven by the use of organocatalysis. To facilitate a multistep synthetic transformations involving alcohol oxidations, we have also developed a series of nitroxyl radical-type organocatalysts that offer highly efficient and selective oxidation alcohols under eco-friendly reaction conditions.
|
| Free Research Field |
有機合成化学
|
