Development of intracellularly-acting supermolesules for regulating cellular functions

2015 Fiscal Year Final Research Report

• Project Area: Molecular Science for Nanomedicine
• Project/Area Number: 23107004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yui Nobuhiko 東京医科歯科大学, 生体材料工学研究所, 教授 (70182665)
• Co-Investigator(Kenkyū-buntansha): KONNO Tomohiro 東京大学, 工学系研究科, 准教授 (80371706) ; SEO Ji-Hun 東京医科歯科大学, 生体材料工学研究所, 助教 (20611544) ; TAMURA Atsushi 東京医科歯科大学, 生体材料工学研究所, 助教 (80631150)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: ポリロタキサン / シクロデキストリン / siRNA / 酵素 / 成長因子

Outline of Final Research Achievements

For regulating cellular functions, we have studied supramolecular polyrotaxanes as novel biomaterials. One of the characteristics seen in polyrotaxanes is the mobility of cyclic compounds, and they can be freely rotational and sliding if any intermolecular forces with the linear chain and the neighboring cyclic compound are eliminated. In particular, polyrotaxanes consisting of α-CD molecules and a poly(ethylene glycol) (PEG) chain are feasible in the structural components as biomaterials.

Free Research Field

バイオマテリアル科学