Clarification of molecular mechanism of lymphatic metastasis and development of new therapy for cancer metastasis

2015 Fiscal Year Final Research Report

• Project Area: Molecular Science for Nanomedicine
• Project/Area Number: 23107009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: Gonda Kohsuke 東北大学, 医学(系)研究科(研究院), 教授 (80375435)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: ナノメディシン / がん / 転移 / ナノ粒子 / 蛍光 / Ｘ線 / イメージング

Outline of Final Research Achievements

Diagnosis of lymph node metastasis is very important for improving cancer prognosis because cancer metastasis tend to occur via lymph vessels rather than blood vessels. To clarify molecular mechanism of lymphatic metastasis and apply the mechanism to development of new diagnostic method for cancer metastasis, we mainly performed three research projects as follows: (1) elucidation of mechanism for lymph node metastasis using unique tumor-bearing mice, (2) development of detection method for lymphatic metastasis using various imaging modalities, and (3) development of pathological diagnosis of surgically-removed primary tumor and metastatic lymph nodes.

Free Research Field

医工学