2015 Fiscal Year Final Research Report

Mechanisms of proteoglycan-mediated experience-dependent neural plasticity

Planned Research

Project Area	Deciphering sugar chain-based signals regulating integrative neuronal functions
Project/Area Number	23110002
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Nagoya University
Principal Investigator	Kadomatsu Kenji 名古屋大学, 医学(系)研究科(研究院), 教授 (80204519)
Project Period (FY)	2011-04-01 – 2016-03-31
Keywords	糖鎖 / 神経可塑性 / 受容体 / 軸索再生
Outline of Final Research Achievements	This study was aimed at elucidating regulatory mechanisms of neural functions by sulfated glycans. Keratan sulfate inhibits axon regeneration. In a set of ocular dominance plasticity, keratan sulfate also regulates functional innervation into binocular region from non-deprived eye through regulation of LTP in the critical period. We also found that chondroitin sulfate and its receptors, PTPRσ and LAR, regulate autophagy, dystrophic endball formation and consequently axon regeneration.
Free Research Field	神経糖鎖生物学